For research use only. Not for therapeutic Use.
Potent RET inhibitor (IC50 value <10 nM) with activity against wild-type RET and its mutants. KEYWORDS: RET inhibitor 2667 | supplier | RET inhibitor | CAS [1980023-80-0] | RTK | GDNF | RET | Receptor tyrosine kinase | oncology | breast cancer | proliferation
| Catalog Number | I047622 |
| CAS Number | 1980023-80-0 |
| Molecular Formula | C26H25FN10O |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-1-[6-(4-fluoropyrazol-1-yl)pyridin-3-yl]ethyl]-3-methyl-5-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]pyridine-2-carboxamide |
| InChI | InChI=1S/C26H25FN10O/c1-14-7-19(25-31-15(2)8-21(34-25)33-22-9-16(3)35-36-22)11-29-24(14)26(38)32-17(4)18-5-6-23(28-10-18)37-13-20(27)12-30-37/h5-13,17H,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t17-/m0/s1 |
| SMILES | CC1=CC(=CN=C1C(=O)N[C@@H](C)C2=CN=C(C=C2)N3C=C(C=N3)F)C4=NC(=CC(=N4)NC5=NNC(=C5)C)C |
| Reference | PE Fleming et al. Preparation of 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors. PCT Int. Appl. (2016), WO 2016127074 A1 20160811 |
