Retigabine 2HCl

For research use only. Not for therapeutic Use.

  • CAT Number: R009164
  • CAS Number: 150812-13-8
  • Molecular Formula: C16H18FN3O2.2HCl
  • Molecular Weight: 376.25
  • Purity: ≥95%
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Retigabine 2HCl (D-23129) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.


Catalog Number R009164
CAS Number 150812-13-8
Molecular Formula C16H18FN3O2.2HCl
Purity ≥95%
Storage 3 years-20°Cpowder
SMILES CCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N.Cl.Cl
Reference

[1] Wickenden AD, et al. Mol Pharmacol. 2000, 58(3):591-600.
[2] Gunthorpe MJ, et al. Epilepsia. 2012, 53(3):412-24.
[3] Stas JI, et al. Sci Rep. 2016, 6:35080.
[4] Blackburn-Munro G, et al. CNS Drug Rev. 2005, 11(1):1-20.
[5] De Sarro G, et al. Naunyn Schmiedebergs Arch Pharmacol. 2001, 363(3):330-6.

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