RETRA

• CAT Number: I011715
• CAS Number: 1036069-26-7
• Molecular Formula: C11H11NO3S2
• Molecular Weight: 269.34
• Purity: ≥95%
• Synonyms: 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone
• InChI: InChI=1S/C11H11NO3S2/c13-8-2-1-7(5-9(8)14)10(15)6-17-11-12-3-4-16-11/h1-2,5,13-14H,3-4,6H2
• InChIKey: OHNNJGHRUIGGBO-UHFFFAOYSA-N
• SMILES: C1CSC(=N1)SCC(=O)C2=CC(=C(C=C2)O)O

RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].

Reference

[1]. J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.
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