For research use only. Not for therapeutic Use.
RETRA(CAT: I011715) is a mutant p53-dependent activator of p73, designed to selectively suppress cancer cells harboring mutant p53. RETRA functions by disrupting the inhibitory complex formed between mutant p53 and p73, leading to the release and reactivation of p73’s tumor-suppressor functions. This results in increased p73 expression and the induction of apoptosis in p53-mutant cancer cells. RETRA is a valuable tool for studying p53-p73 signaling dynamics and holds promise in anticancer strategies aimed at targeting tumors with dysfunctional p53 pathways.[1].
| CAS Number | 1036069-26-7 |
| Synonyms | 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone |
| Molecular Formula | C11H12ClNO3S2 |
| Purity | ≥95% |
| IUPAC Name | 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone;hydrochloride |
| InChI | InChI=1S/C11H11NO3S2/c13-8-2-1-7(5-9(8)14)10(15)6-17-11-12-3-4-16-11/h1-2,5,13-14H,3-4,6H2 |
| InChIKey | OHNNJGHRUIGGBO-UHFFFAOYSA-N |
| SMILES | C1CSC(=N1)SCC(=O)C2=CC(=C(C=C2)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
