Reversin 121

• CAT Number: R065872
• CAS Number: 174630-04-7
• Molecular Formula: C34H47N3O9
• Molecular Weight: 641.76
• Purity: ≥95%
• Synonyms: 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester N-[(1,1-dimethylethoxy)carbonyl]-L-a-aspartyl-N6-[(phenylmethoxy)carbonyl]-L-lysine
• Target: P-glycoprotein
• Storage: -20°C
• IUPAC Name: tert-butyl (2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxo-4-phenylmethoxybutanoyl]amino]-6-(phenylmethoxycarbonylamino)hexanoate
• InChI: InChI=1S/C34H47N3O9/c1-33(2,3)45-30(40)26(19-13-14-20-35-31(41)44-23-25-17-11-8-12-18-25)36-29(39)27(37-32(42)46-34(4,5)6)21-28(38)43-22-24-15-9-7-10-16-24/h7-12,15-18,26-27H,13-14,19-23H2,1-6H3,(H,35,41)(H,36,39)(H,37,42)/t26-,27-/m0/s1
• InChIKey: SVNKEDMVAQBLLN-SVBPBHIXSA-N
• SMILES: CC(C)(C)OC(=O)[C@H](CCCCNC(=O)OCC1=CC=CC=C1)NC(=O)[C@H](CC(=O)OCC2=CC=CC=C2)NC(=O)OC(C)(C)C

Reversin 121(CAT: R065872) is a small molecule known for its ability to inhibit the activity of certain ATP-binding cassette (ABC) transporters, particularly those involved in multidrug resistance (MDR) in cancer cells. By blocking these transporters, Reversin 121 can prevent the efflux of chemotherapeutic drugs from cancer cells, thereby enhancing the efficacy of anticancer treatments. This compound is of significant interest in cancer research, especially in overcoming drug resistance in tumors. Its potential to restore the sensitivity of resistant cancer cells to chemotherapy makes Reversin 121 a promising candidate in the development of adjunct therapies for cancer treatment.

Reference

1.Sharom, F.J.,Yu, X.,Lu, P., et al. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells. Biochemical Pharmacology 58(4), 571-586 (1999).