Rezivertinib analogue 1

• CAT Number: I042907
• CAS Number: 2227103-37-7
• Molecular Formula: C27H33N7O2
• Molecular Weight: 487.60
• Purity: ≥95%
• Synonyms: N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]acetamide
• InChI: InChI=1S/C27H33N7O2/c1-18(35)29-22-15-23(26(36-6)16-25(22)33(4)14-13-32(2)3)31-27-28-12-11-21(30-27)20-17-34(5)24-10-8-7-9-19(20)24/h7-12,15-17H,13-14H2,1-6H3,(H,29,35)(H,28,30,31)
• InChIKey: FZPRMSLRRIEUNO-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC(=C(C=C1N(C)CCN(C)C)OC)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C

Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer[1].

Reference

[1]. Huijuan Jia, et al. The methanesulfonic acid uncommon preparation method for Buddhist nun’s process contaminants difficult to understand. Patent CN108017620A.