RG 13022

• CAT Number: I009020
• CAS Number: 136831-48-6
• Molecular Formula: C16H14N2O2
• Molecular Weight: 266.30
• Purity: ≥95%
• Synonyms: RG 13022; RG13022; RG-13022.Tyrphostin RG 13022;3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-
• Target: Protein Tyrosine Kinase/RTK
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (E)-3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile
• InChI: InChI=1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3/b14-8-
• InChIKey: DBGZNJVTHYFQJI-ZSOIEALJSA-N
• SMILES: COC1=C(C=C(C=C1)/C=C(/C#N)\C2=CN=CC=C2)OC

RG 13022（Cat No.:I009020）is an investigational compound being developed by Roche for its potential use in treating neurological disorders, particularly Alzheimer’s disease. It is designed as a selective modulator of certain receptors in the brain, with the aim of improving cognitive function and reducing neurodegeneration. RG 13022 works by targeting pathways involved in memory and learning processes, potentially offering a novel therapeutic approach for diseases characterized by cognitive decline. Although early preclinical studies have shown promise, further clinical trials are necessary to evaluate its safety, efficacy, and long-term effects.