RG14620

For research use only. Not for therapeutic Use.

  • CAT Number: I009023
  • CAS Number: 136831-49-7
  • Molecular Formula: C14H8Cl2N2
  • Molecular Weight: 275.13
  • Purity: ≥95%
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RG14620 is an EGFR inhibitor with an IC50 of 3 μM.
RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible[2].
RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals[2].


Catalog Number I009023
CAS Number 136831-49-7
Synonyms

(E)-3-(3,5-dichlorophenyl)-2-pyridin-3-ylprop-2-enenitrile

Molecular Formula C14H8Cl2N2
Purity ≥95%
InChI InChI=1S/C14H8Cl2N2/c15-13-5-10(6-14(16)7-13)4-12(8-17)11-2-1-3-18-9-11/h1-7,9H/b12-4-
InChIKey TYXIVBJQPBWBHO-QCDXTXTGSA-N
SMILES C1=CC(=CN=C1)C(=CC2=CC(=CC(=C2)Cl)Cl)C#N
Reference

[1]. Sagara Y, et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem. 2002 Sep 27;277(39):36204-15.
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[2]. Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5.
 [Content Brief]

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