For research use only. Not for therapeutic Use.
RG7388 (Cat No.: I000906) is a small-molecule inhibitor that targets the mouse double minute 2 (MDM2) protein. MDM2 is an important negative regulator of the tumor suppressor protein p53. By binding to p53, MDM2 promotes its degradation and inhibits its transcriptional activity. RG7388 disrupts the MDM2-p53 interaction, leading to the stabilization and activation of p53. This activation of p53 can induce cell cycle arrest, and apoptosis, and inhibit tumor growth. RG7388 has shown promise as a potential anticancer agent, particularly in tumors with wild-type p53 and overexpression of MDM2. It represents a novel therapeutic strategy for reactivating p53 function and treating various types of cancer.
| Catalog Number | I000906 |
| CAS Number | 1229705-06-9 |
| Synonyms | 4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid |
| Molecular Formula | C₃₁H₂₉Cl₂F₂N₃O₄ |
| Purity | 98% |
| Target | Macrophage colony-stimulating factor 1 receptor |
| Target Protein | P07333 |
| Solubility | DMSO: ≥ 45 mg/mL |
| Appearance | Solid |
| Storage | Dry, dark and at 2 - 8 °C for six months or -20°C for two years. |
| IC50 | IC50: 6 nM (p53-MDM2) |
| IUPAC Name | 4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid |
| InChI | InChI=1S/C31H29Cl2F2N3O4/c1-30(2,3)14-24-31(15-36,19-10-9-17(32)13-21(19)34)25(18-6-5-7-20(33)26(18)35)27(38-24)28(39)37-22-11-8-16(29(40)41)12-23(22)42-4/h5-13,24-25,27,38H,14H2,1-4H3,(H,37,39)(H,40,41)/t24-,25-,27+,31-/m0/s1 |
| InChIKey | TVTXCJFHQKSQQM-LJQIRTBHSA-N |
| SMILES | CC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F |
| Reference | 1 J Med Chem. 2013 Jul 25;56(14):5979-83. doi: 10.1021/jm400487c. Epub 2013 Jul 16.<br /> |
