For research use only. Not for therapeutic Use.
RGB-286638（Cat No.:I004882）is a multi-targeted cyclin-dependent kinase (CDK) inhibitor with potent anti-cancer properties. It inhibits several CDKs, including CDK1, CDK2, CDK5, CDK7, and CDK9, which are involved in regulating the cell cycle and transcription. By blocking these kinases, RGB-286638 induces cell cycle arrest and apoptosis in cancer cells, particularly in rapidly proliferating tumors. Preclinical studies have shown its efficacy in various cancers, including leukemia and solid tumors. Its broad-spectrum inhibition of CDKs makes it a promising candidate for cancer therapy, with potential to be used as a monotherapy or in combination with other treatments.
| Catalog Number | I004882 |
| CAS Number | 784210-87-3 |
| Synonyms | 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea;dihydrochloride |
| Molecular Formula | C29H37Cl2N7O4 |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 1 nM/2 nM/3 nM/4 nM/5 nM(cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5) |
| IUPAC Name | 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea;dihydrochloride |
| InChI | InChI=1S/C29H35N7O4.2ClH/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36;;/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38);2*1H |
| InChIKey | WJVMGQMXUBAAPL-UHFFFAOYSA-N |
| SMILES | COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6.Cl.Cl |
| Reference | <p style=/line-height:25px/> |
