For research use only. Not for therapeutic Use.
RGFP966（Cat No.:I001386）is a selective histone deacetylase 3 (HDAC3) inhibitor, widely used in research to explore epigenetic regulation of gene expression. By inhibiting HDAC3, RGFP966 promotes histone acetylation, leading to increased transcriptional activity of specific genes involved in neuronal plasticity, memory formation, and neuroprotection. This compound has shown promise in preclinical studies related to cognitive enhancement, neurodegenerative diseases, and cancer therapy. Its selectivity for HDAC3 over other HDAC isoforms makes it a valuable tool for studying HDAC3’s role in cellular processes and potential therapeutic interventions.
| Catalog Number | I001386 |
| CAS Number | 1357389-11-7 |
| Molecular Formula | C21H19FN4O |
| Purity | ≥95% |
| Target | HDAC |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 80 nM |
| IUPAC Name | (E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide |
| InChI | InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+ |
| InChIKey | BLVQHYHDYFTPDV-VCABWLAWSA-N |
| SMILES | C1=CC=C(C=C1)/C=C/CN2C=C(C=N2)/C=C/C(=O)NC3=C(C=C(C=C3)F)N |
| Reference | </br>1:HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity. Leus NG, van der Wouden PE, van den Bosch T, Hooghiemstra WT, Ourailidou ME, Kistemaker LE, Bischoff R, Gosens R, Haisma HJ, Dekker FJ.Biochem Pharmacol. 2016 May 15;108:58-74. doi: 10.1016/j.bcp.2016.03.010. Epub 2016 Mar 16. PMID: 26993378 Free PMC Article</br>2:Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation. Bieszczad KM, Bechay K, Rusche JR, Jacques V, Kudugunti S, Miao W, Weinberger NM, McGaugh JL, Wood MA.J Neurosci. 2015 Sep 23;35(38):13124-32. doi: 10.1523/JNEUROSCI.0914-15.2015. PMID: 26400942 Free PMC Article |
