For research use only. Not for therapeutic Use.
RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1].
RH01386 (270 nM-70 μM; 72 hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM[1].
RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells[1].
| Catalog Number | I017144 |
| CAS Number | 301177-36-6 |
| Synonyms | 4-cyclohexyl-2-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-6-oxo-1H-pyrimidine-5-carbonitrile |
| Molecular Formula | C18H15F3N4O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H15F3N4O3S/c19-18(20,21)11-6-7-14(13(8-11)25(27)28)29-17-23-15(10-4-2-1-3-5-10)12(9-22)16(26)24-17/h6-8,10H,1-5H2,(H,23,24,26) |
| InChIKey | BVWCKDMNROTYMZ-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)C2=C(C(=O)NC(=N2)SC3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-])C#N |
| Reference | [1]. Tran K, et al. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.ACS Chem Biol. 2014 Dec 19;9(12):2796-806. |
