RH01617

• CAT Number: I035547
• CAS Number: 302333-18-2
• Molecular Formula: C22H26N2O5S
• Molecular Weight: 430.52
• Purity: 98%
• Synonyms: RH01617; RH-01617; RH 01617
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[(4-Butoxyphenyl)sulfonyl]-L-tryptophan methyl esterMethyl (S)-2-(4-butoxybenzenesulfonamido)-3-(1H-indol-3-yl)propanoate
• InChI: InChI=1S/C22H26N2O5S/c1-3-4-13-29-17-9-11-18(12-10-17)30(26,27)24-21(22(25)28-2)14-16-15-23-20-8-6-5-7-19(16)20/h5-12,15,21,23-24H,3-4,13-14H2,1-2H3/t21-/m0/s1
• InChIKey: BRMKFAYWVMIHQZ-NRFANRHFSA-N
• SMILES: O=C(OC)[C@H](CC1=CNC2=C1C=CC=C2)NS(=O)(C3=CC=C(OCCCC)C=C3)=O

RH01617(CAT: I035547) is a potent inhibitor of the Kv1.5 potassium channel, a critical regulator of atrial action potential repolarization. By selectively targeting Kv1.5, RH01617 modulates atrial electrical activity, reducing atrial reentry and excitability, which are key contributors to atrial fibrillation (AF). Kv1.5 has been identified as an efficacious and safe therapeutic target for AF treatment, as it is predominantly expressed in the atria and not in the ventricles, minimizing proarrhythmic risks. RH01617 is a valuable tool in cardiovascular research, particularly for investigating atrial-selective antiarrhythmic therapies and advancing our understanding of AF pathophysiology and treatment.