Ribocil-C

• CAT Number: I002370
• CAS Number: 1825355-56-3
• Molecular Formula: C21H21N7OS
• Molecular Weight: 419.50
• Purity: ≥95%
• Target: Bacterial
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IUPAC Name: 2-[(3S)-1-[(1-pyrimidin-2-ylimidazol-4-yl)methyl]piperidin-3-yl]-4-thiophen-2-yl-1H-pyrimidin-6-one
• InChI: InChI=1S/C21H21N7OS/c29-19-10-17(18-5-2-9-30-18)25-20(26-19)15-4-1-8-27(11-15)12-16-13-28(14-24-16)21-22-6-3-7-23-21/h2-3,5-7,9-10,13-15H,1,4,8,11-12H2,(H,25,26,29)/t15-/m0/s1
• InChIKey: UVDVCDUBJWYRJW-HNNXBMFYSA-N
• SMILES: C1C[C@@H](CN(C1)CC2=CN(C=N2)C3=NC=CC=N3)C4=NC(=CC(=O)N4)C5=CC=CS5

Ribocil-C（Cat No.:I002370）is a selective and potent inhibitor of bacterial riboflavin biosynthesis, specifically targeting the enzyme ribD in the riboflavin pathway. This small molecule has shown promise as a potential antimicrobial agent due to its ability to disrupt the synthesis of riboflavin, a vital cofactor for bacterial growth. Ribocil-C demonstrates broad-spectrum activity against various bacterial strains, including drug-resistant pathogens, by inhibiting essential metabolic processes. It holds potential for further development as an adjunct therapy in treating infections caused by resistant bacteria, offering a novel approach in combating antimicrobial resistance.

Reference

[1]. Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.