Ribocil-C (R enantiomer)

• CAT Number: I020453
• CAS Number: 2177266-81-6
• Molecular Formula: C₂₁H₂₁N₇OS
• Molecular Weight: 419.50
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: 2-[(3R)-1-[(1-pyrimidin-2-ylimidazol-4-yl)methyl]piperidin-3-yl]-4-thiophen-2-yl-1H-pyrimidin-6-one
• InChI: InChI=1S/C21H21N7OS/c29-19-10-17(18-5-2-9-30-18)25-20(26-19)15-4-1-8-27(11-15)12-16-13-28(14-24-16)21-22-6-3-7-23-21/h2-3,5-7,9-10,13-15H,1,4,8,11-12H2,(H,25,26,29)/t15-/m1/s1
• InChIKey: UVDVCDUBJWYRJW-OAHLLOKOSA-N
• SMILES: C1C[C@H](CN(C1)CC2=CN(C=N2)C3=NC=CC=N3)C4=NC(=CC(=O)N4)C5=CC=CS5

Ribocil-C (R enantiomer)（Cat No.:I020453）is a synthetic small-molecule compound that selectively targets bacterial riboflavin (vitamin B2) biosynthesis, acting as a potent inhibitor of the riboflavin riboswitch. By binding to this riboswitch, it disrupts the essential riboflavin pathway, effectively inhibiting bacterial growth, especially in antibiotic-resistant strains. As the (R) enantiomer, Ribocil-C demonstrates enhanced binding affinity and specificity, making it a valuable tool in antibacterial research. Its unique mechanism offers a novel approach to developing treatments against resistant bacteria, positioning it as a promising candidate in antimicrobial drug discovery.

Reference

[1]. Wang H, et al. Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch DisruptRiboflavin Homeostasis in an Infectious Setting. Cell Chem Biol. 2017 May 18;24(5):576-588.