Rifamide

• CAT Number: I035576
• CAS Number: 2750-76-7
• Molecular Formula: C43H58N2O13
• Molecular Weight: 810.94
• Purity: 98%
• Synonyms: Rifamide; NSC 133099; NSC133099; NSC-133099; Rifamida; Rifamidum; Rifamycin M14
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-27-[2-(diethylamino)-2-oxoethoxy]-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
• InChI: InChI=1S/C43H58N2O13/c1-12-45(13-2)31(47)20-55-30-19-28-38(51)33-32(30)34-40(26(8)37(33)50)58-43(10,41(34)52)56-18-17-29(54-11)23(5)39(57-27(9)46)25(7)36(49)24(6)35(48)21(3)15-14-16-22(4)42(53)44-28/h14-19,21,23-25,29,35-36,39,48-51H,12-13,20H2,1-11H3,(H,44,53)/b15-14+,18-17+,22-16-/t21-,23+,24+,25+,29-,35-,36+,39+,43-/m0/s1
• InChIKey: VFYNXKZVOUXHDX-VDPUEHCXSA-N
• SMILES: CCN(CC)C(=O)COC1=C2C3=C(C(=C1)NC(=O)/C(=C\C=C\[C@@H]([C@@H]([C@H]([C@H]([C@H]([C@@H]([C@@H]([C@H](/C=C/O[C@@]4(C(=O)C2=C(O4)C(=C3O)C)C)OC)C)OC(=O)C)C)O)C)O)C)/C)O

Rifamide(CAT: I035576) is a derivative of rifamycin, belonging to the rifamycin antibiotic family, known for its broad-spectrum antibacterial activity. Like other rifamycins, Rifamide functions by inhibiting DNA-dependent RNA polymerase in bacteria, which blocks RNA synthesis and ultimately leads to bacterial cell death. This mechanism makes Rifamide effective against Gram-positive and Gram-negative bacteria, particularly in treating infections caused by Mycobacterium tuberculosis and other mycobacterial species. Rifamide is being explored in infectious disease research for its potential role in combating tuberculosis and other bacterial infections, especially in the context of antibiotic resistance.