Rifampicin

• CAT Number: I001254
• CAS Number: 13292-46-1
• Molecular Formula: C43H58N4O12
• Molecular Weight: 823.00
• Purity: ≥95%
• Target: Antibiotic
• Solubility: methanol:25 mg/ml; DMSO:25 mg/ml
• Storage: 3 years -20C powder
• IUPAC Name: [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
• InChI: InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
• InChIKey: JQXXHWHPUNPDRT-WLSIYKJHSA-N
• SMILES: C[C@H]1/C=C/C=C(\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C

Rifampicin（Cat No.:I001254）is a broad-spectrum antibiotic used primarily in the treatment of tuberculosis (TB) and other bacterial infections. It works by inhibiting bacterial RNA polymerase, thereby preventing RNA synthesis and inhibiting bacterial growth. Rifampicin is highly effective against Mycobacterium tuberculosis, the causative agent of TB, and is often used in combination with other drugs to prevent resistance. It also has activity against other Gram-positive and Gram-negative bacteria. This antibiotic is metabolized in the liver and has a notable interaction with cytochrome P450 enzymes, affecting the metabolism of other drugs.

Reference

[1]. Hofmann, A.F., Rifampicin and treatment of cholestatic pruritus. Gut, 2002. 51(5): p. 756-7.

[2]. Calvori, C., et al., Effect of rifamycin on protein synthesis. Nature, 1965. 207(995): p. 417-8.