Riluzole

• CAT Number: A000389
• CAS Number: 1744-22-5
• Molecular Formula: C8H5F3N2OS
• Molecular Weight: 234.2
• Purity: ≥95%
• Synonyms: 1744-22-5; Rilutek; 2-Amino-6-(trifluoromethoxy)benzothiazole; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
• Target: Sodium Channel
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
• InChIKey: FTALBRSUTCGOEG-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N

Riluzole is a drug used to treat amyotrophic lateral sclerosis. It delays the onset of ventilator-dependence or tracheostomy in selected patients and may increase survival by approximately two to three months.

Reference

1: Can H, Aydoseli A, Gömleksiz C, Göker B, Altunrende ME, Dolgun M, Sencer A.
Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor
antagonist riluzole in experimental spinal cord injury. Ulus Travma Acil Cerrahi
Derg. 2017;23(6):452-458. doi: 10.5505/tjtes.2017.09694. PubMed PMID: 29115658.

2: Datta P, Rewers-Felkins K, Aurora N, Baker T, Hale TW. Estimation of Riluzole
Levels in Human Milk and Infant Exposure During Its Use in a Patient With ALS. J
Hum Lact. 2017 Nov 1:890334417737042. doi: 10.1177/0890334417737042. [Epub ahead
of print] PubMed PMID: 29100479.

3: Grant P, Farmer C, Song J, Kish T, Swedo S. Riluzole Serum Concentration in
Pediatric Patients Treated for Obsessive-Compulsive Disorder. J Clin
Psychopharmacol. 2017 Dec;37(6):713-716. doi: 10.1097/JCP.0000000000000797.
PubMed PMID: 29045303.

4: Sepulveda-Orengo MT, Healey KL, Kim R, Auriemma AC, Rojas J, Woronoff N,
Hyppolite R, Reissner KJ. Riluzole Impairs Cocaine Reinstatement and Restores
Adaptations in Intrinsic Excitability and GLT-1 Expression.
Neuropsychopharmacology. 2017 Oct 9. doi: 10.1038/npp.2017.244. [Epub ahead of
print] PubMed PMID: 28990593.

5: Sarkar M, Grossman RG, Toups EG, Chow DS. UPLC-MS/MS assay of riluzole in
human plasma and cerebrospinal fluid (CSF): Application in samples from spinal
cord injured patients. J Pharm Biomed Anal. 2017 Nov 30;146:334-340. doi:
10.1016/j.jpba.2017.08.045. Epub 2017 Sep 1. PubMed PMID: 28917164.

6: Falcão de Campos C, de Carvalho M. Riluzole-induced recurrent pancreatitis. J
Clin Neurosci. 2017 Nov;45:153-154. doi: 10.1016/j.jocn.2017.08.032. Epub 2017
Sep 1. PubMed PMID: 28867362.

7: González-Fernández C, Güell R, Anton A. Pulmonary toxicity by riluzole. Med
Clin (Barc). 2017 Aug 29. pii: S0025-7753(17)30569-9. doi:
10.1016/j.medcli.2017.06.052. [Epub ahead of print] English, Spanish. PubMed
PMID: 28864086.

8: Yamamoto S, Ushio S, Egashira N, Kawashiri T, Mitsuyasu S, Higuchi H, Ozawa N,
Masuguchi K, Ono Y, Masuda S. Excessive spinal glutamate transmission is involved
in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a
prophylactic drug. Sci Rep. 2017 Aug 29;7(1):9661. doi:
10.1038/s41598-017-08891-1. PubMed PMID: 28851920; PubMed Central PMCID:
PMC5574967.

9: Sugiyama A, Yamada M, Saitoh A, Oka JI, Yamada M. Administration of riluzole
to the basolateral amygdala facilitates fear extinction in rats. Behav Brain Res.
2018 Jan 15;336:8-14. doi: 10.1016/j.bbr.2017.08.031. Epub 2017 Aug 24. PubMed
PMID: 28843863.

10: Andreasen SR, Lundbye CJ, Christensen TB, Thielsen KD, Schmitt-John T, Holm
MM. Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of
amyotrophic lateral sclerosis substantiated by riluzole and diazepam. Neurosci
Lett. 2017 Sep 29;658:85-90. doi: 10.1016/j.neulet.2017.08.033. Epub 2017 Aug 18.
PubMed PMID: 28823891.