Rimegepant

• CAT Number: I009041
• CAS Number: 1289023-67-1 (free base); 1374024-48-2 (sulfate)
• Molecular Formula: C28H28F2N6O3
• Molecular Weight: 534.56
• Purity: 95%
• Synonyms: BMS-927711; BMS 927711; BMS927711; Rimegepant;(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
• Target: CGRP receptor
• Target Protein: Q16602
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IC50: 0.14 nM(CGRP receptor antagonist)
• IUPAC Name: [(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
• InChI: InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
• InChIKey: KRNAOFGYEFKHPB-ANJVHQHFSA-N
• SMILES: C1C[C@H](C2=C(C=CC=N2)[C@H]([C@@H]1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6

Rimegepant（Cat No.:I009041）is an oral calcitonin gene-related peptide (CGRP) receptor antagonist used for the acute treatment of migraine and the preventive treatment of episodic migraines. By blocking CGRP receptors, Rimegepant reduces the vasodilation and neuroinflammatory responses that contribute to migraine headaches. Its fast-acting, non-opioid mechanism provides relief from migraine symptoms without the cardiovascular risks associated with traditional migraine medications. With a favorable safety profile and long-lasting efficacy, Rimegepant offers a valuable treatment option for both immediate migraine relief and long-term prevention of migraine attacks.