For research use only. Not for therapeutic Use.
Rimeporide（Cat No.:M045543） is a pharmaceutical compound developed as a selective sodium-hydrogen exchanger-1 (NHE-1) inhibitor. This drug targets the NHE-1 enzyme, which plays a critical role in cellular pH regulation and sodium handling. By inhibiting this enzyme, rimeporide helps to prevent cellular overload with sodium and calcium, which can contribute to cardiac stress and damage under conditions like ischemia. Initially explored for its potential in treating heart failure, its applications have expanded to include research into treatments for muscular dystrophy, particularly in managing the cellular dysfunction associated with this group of diseases.
| Catalog Number | M045543 |
| CAS Number | 187870-78-6 |
| Synonyms | Rimeporide |
| Molecular Formula | C10H15NO2S |
| Purity | ≥95% |
| Target | Na+/H+ Exchanger (NHE) |
| Storage | Desiccate at -20C |
| IUPAC Name | N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide |
| InChI | InChI=1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15) |
| InChIKey | GROMEQPXDKRRIE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1C(=O)N=C(N)N)S(=O)(=O)C)S(=O)(=O)C |
