| Synonyms | (11β,16α,17β)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one; 11β-Hydroxy-16α,17,21-trimethylpregna-1,4-diene-3,20-dione; 11β-Hydroxy-16α,17α,21-trimethyl-5α-pregna-1,4-diene-3,20-dione; Org 6216; Rimexel; Rimexolone; Trimexolone;
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| IUPAC Name | (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| InChI | InChI=1S/C24H34O3/c1-6-20(27)24(5)14(2)11-18-17-8-7-15-12-16(25)9-10-22(15,3)21(17)19(26)13-23(18,24)4/h9-10,12,14,17-19,21,26H,6-8,11,13H2,1-5H3/t14-,17+,18+,19+,21-,22+,23+,24-/m1/s1 |
| Reference | <br />
1:Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells. Spies CM, Gaber T, Hahne M, Naumann L, Tripmacher R, Schellmann S, Stahn C, Burmester GR, Radbruch A, Buttgereit F.Immunol Lett. 2010 Jun 15;131(1):24-32. doi: 10.1016/j.imlet.2010.03.009. Epub 2010 Apr 2. PMID: 20363256<br />
2:[0.1% dexamathasone and 1% rimexolone. A comparative study in the postoperative treatment after cataract extraction]. Vico-Ruiz E, Benítez-Del-Castillo-Sánchez JM, Cuiña-Sardiña R, Martínez-De-La-Casa JM, García-Sánchez J.Arch Soc Esp Oftalmol. 2009 Jun;84(6):299-304. Spanish. PMID: 19568990 Free Article<br />
3:Rimexolone 1% versus prednisolone acetate in preventing early postoperative inflammation after cataract surgery. Kavuncu S, Horoz H, Ardagil A, Erbil HH.Int Ophthalmol. 2008 Aug;28(4):281-5. Epub 2007 Aug 31. PMID: 17762913<br />
4:Effect of topical dexamethasone versus rimexolone on middle ear inflammation in experimental otitis media with effusion. Florea A, Zwart JE, Lee CW, Depew A, Park SK, Inman J, Wareham R, Johnson K, John E, Wall GM, Jung T.Acta Otolaryngol. 2006 Sep;126(9):910-5. PMID: 16864486<br />
5:[Efficacy of prednisolone and rimexolone in HLA-B27 positive patients with acute anterior uveitis]. Arellanes-García L, Padilla-Aguilar G, Navarro-López P, Espinoza-Martínez C.Gac Med Mex. 2005 Sep-Oct;141(5):363-6. Spanish. PMID: 16353881<br />
6:Efficacy and safety of 1% rimexolone versus 1% prednisolone acetate in the treatment of anterior uveitis–a randomized triple masked study. Biswas J, Ganeshbabu TM, Raghavendran SR, Raizada S, Mondkar SV, Madhavan HN.Int Ophthalmol. 2004 May;25(3):147-53. PMID: 15847313<br />
7:Comparison of prednisolone 1%, rimexolone 1% and ketorolac tromethamine 0.5% after cataract extraction: a prospective, randomized, double-masked study. Hirneiss C, Neubauer AS, Kampik A, Schönfeld CL.Graefes Arch Clin Exp Ophthalmol. 2005 Aug;243(8):768-73. Epub 2005 Mar 9. PMID: 15756571<br />
8:Efficacy and safety of rimexolone 1% versus prednisolone acetate 1% in the control of postoperative inflammation following phacoemulsification cataract surgery. Yaylali V, Ozbay D, Tatlipinar S, Yildirim C, Ozden S.Int Ophthalmol. 2004 Jan;25(1):65-8. PMID: 15085979<br />
9:Ocular-hypertensive and anti-inflammatory response to rimexolone therapy in children. Fan DS, Yu CB, Chiu TY, Wong CY, Ng JS, Pang CP, Lam DS.Arch Ophthalmol. 2003 Dec;121(12):1716-21. PMID: 14662591<br />
10:Rimexolone-induced intraocular pressure elevation. Cazabon S, Morrell AJ.Eye (Lond). 2001 Oct;15(Pt 5):663-4. Review. No abstract available. PMID: 11702986
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