RIP1 kinase inhibitor 1

• CAT Number: I018498
• CAS Number: 2095515-38-9
• Molecular Formula: C₂₄H₂₀ClN₅O₃
• Molecular Weight: 461.9
• Purity: ≥95%
• Storage: 4°C, away from moisture and light
• IUPAC Name: (3S)-3-(2-benzyl-3-chloro-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepine-8-carbonitrile
• InChI: InChI=1S/C24H20ClN5O3/c1-28-18-8-7-16(12-26)11-20(18)33-14-19(23(28)31)29-10-9-17-21(24(29)32)27-30(22(17)25)13-15-5-3-2-4-6-15/h2-8,11,19H,9-10,13-14H2,1H3/t19-/m0/s1
• InChIKey: JWKONLKXWPCOJF-IBGZPJMESA-N
• SMILES: CN1C2=C(C=C(C=C2)C#N)OCC(C1=O)N3CCC4=C(N(N=C4C3=O)CC5=CC=CC=C5)Cl

RIP1 kinase inhibitor 1 (Cat No.:I018498) is a potent and selective inhibitor of receptor-interacting protein 1 kinase, a key player in the regulation of cell death and inflammation. RIP1i is structurally distinct from other RIP1 inhibitors and binds to an allosteric site of RIP1. It has demonstrated therapeutic potential for the treatment of inflammatory and immune-related disorders, as well as for the prevention of necroptosis-associated diseases.

Reference

[1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, OrallyAvailable, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409.