RIP1/RIP3/MLKL activator 1

• CAT Number: I043874
• CAS Number: 2682850-41-3
• Molecular Formula: C43H56N4O3
• Molecular Weight: 676.93
• Purity: ≥95%
• Synonyms: (2R,4aS,6aR,6aS,14aS)-N-[[1-[(4-tert-butylphenyl)methyl]triazol-4-yl]methyl]-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxamide
• InChI: InChI=1S/C43H56N4O3/c1-27-31-14-15-34-41(7,32(31)22-33(48)36(27)49)19-21-43(9)35-23-40(6,17-16-39(35,5)18-20-42(34,43)8)37(50)44-24-30-26-47(46-45-30)25-28-10-12-29(13-11-28)38(2,3)4/h10-15,22,26,35,49H,16-21,23-25H2,1-9H3,(H,44,50)/t35?,39-,40-,41+,42-,43+/m1/s1
• InChIKey: QLFCJGYFBTYJGC-RSWNTZNOSA-N
• SMILES: CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5(C4C[C@](CC5)(C)C(=O)NCC6=CN(N=N6)CC7=CC=C(C=C7)C(C)(C)C)C)C)C)C)O

RIP1/RIP3/MLKL activator 1（Cat No.:I043874）is a small molecule that activates the necroptosis signaling pathway, which involves the receptor-interacting protein kinases RIP1 and RIP3, and the mixed-lineage kinase domain-like protein (MLKL). Necroptosis is a regulated form of cell death, distinct from apoptosis, and plays a role in inflammation, immune responses, and disease pathology. By activating RIP1, RIP3, and MLKL, this compound can induce necroptotic cell death, offering potential therapeutic applications in cancer, infection, and inflammatory diseases. It is being researched for its ability to modulate cell death pathways in various disease contexts.