RIP2 kinase inhibitor 1

• CAT Number: I001634
• CAS Number: 1423186-80-4
• Molecular Formula: C21H22N4O4S2
• Molecular Weight: 458.55
• Purity: ≥95%
• Target: RIP kinase
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at RT
• IUPAC Name: 2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinazolin-7-yl]oxyethanol
• InChI: 1S/C21H22N4O4S2/c1-21(2,3)31(27,28)19-9-14-15(10-17(19)29-7-6-26)22-11-23-20(14)25-13-4-5-18-16(8-13)24-12-30-18/h4-5,8-12,26H,6-7H2,1-3H3,(H,22,23,25)
• InChIKey: UHDOJINBFLDQJM-UHFFFAOYSA-N
• SMILES: CC(C)(C)S(=O)(=O)C1=C(C=C2C(=C1)C(=NC=N2)NC3=CC4=C(C=C3)SC=N4)OCCO

RIP2 kinase inhibitor 1(CAT: I001634) is a small molecule compound that acts as an inhibitor of receptor-interacting protein kinase 2 (RIP2). RIP2, also known as RIPK2, is an intracellular serine/threonine kinase involved in innate immune signaling pathways, particularly in the regulation of inflammatory responses. By inhibiting RIP2 kinase activity, RIP2 kinase inhibitor 1 can modulate immune signaling and potentially attenuate excessive inflammatory responses. This compound has shown promise as a therapeutic target for inflammatory and autoimmune diseases. Further research is being conducted to explore its pharmacological properties and therapeutic applications.

Reference

[1]. Linda N. Casillas, et al. Prodrugs of amino quinazoline kinase inhibitor. PCT Int. Appl. (2014), WO 2014043446 A1 20140320.