RIP2 kinase inhibitor 2

• CAT Number: I002009
• CAS Number: 1581270-11-2
• Molecular Formula: C21H28N4O4S
• Molecular Weight: 432.54
• Purity: ≥95%
• Target: RIP2 Kinase [1]
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 6-tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)quinolin-4-amine
• InChI: InChI=1S/C21H28N4O4S/c1-13-14(2)24-25-20(13)23-16-7-8-22-17-12-18(29-10-9-28-6)19(11-15(16)17)30(26,27)21(3,4)5/h7-8,11-12H,9-10H2,1-6H3,(H2,22,23,24,25)
• InChIKey: QODPGRHWJBWTJC-UHFFFAOYSA-N
• SMILES: CC1=C(NN=C1NC2=C3C=C(C(=CC3=NC=C2)OCCOC)S(=O)(=O)C(C)(C)C)C

RIP2 kinase inhibitor 2 (Cat No.:I002009) is a small molecule compound that selectively inhibits the activity of receptor-interacting protein kinase 2 (RIP2). By targeting RIP2, a key regulator of inflammatory signaling pathways, this inhibitor has the potential to modulate immune responses and mitigate inflammatory conditions. Its specificity towards RIP2 suggests it could be used in the treatment of diseases associated with abnormal immune activation, such as autoimmune disorders and inflammatory bowel disease.

Reference

[1]. Linda N. Casillas, et al. Amino-quinolines as kinase inhibitors. PCT Int. Appl. (2014), WO 2014043437 A1 20140320.