For research use only. Not for therapeutic Use.
RIPA-56（Cat No.:I009043） is a powerful and selective inhibitor of Receptor-Interacting Protein 1 (RIP1), also known as RIPK1. It possesses high potency, metabolic stability, and selectivity for RIP1. By targeting RIP1, RIPA-56 can modulate the necroptotic pathway, a programmed cell death process implicated in various diseases, including inflammation, neurodegenerative disorders, and cancer. The stability of RIPA-56 allows for prolonged activity and improved pharmacokinetic properties. Its selectivity ensures minimal off-target effects, making RIPA-56 a valuable tool for studying RIP1-mediated pathways and a potential therapeutic agent for RIP1-associated diseases.
| Catalog Number | I009043 |
| CAS Number | 1956370-21-0 |
| Synonyms | RIPA-56; RIPA-56; RIPA-56.;N-benzyl-N-hydroxy-2,2-dimethylbutanamide |
| Molecular Formula | C13H19NO2 |
| Purity | ≥95% |
| Target | RIP1 inhibitor |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IC50 | 13 nM |
| IUPAC Name | N-benzyl-N-hydroxy-2,2-dimethylbutanamide |
| InChI | InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3 |
| InChIKey | AVYVHIKSFXVDBG-UHFFFAOYSA-N |
| SMILES | CCC(C)(C)C(=O)N(CC1=CC=CC=C1)O |
| Reference | </br>1: Ren Y, Su Y, Sun L, He S, Meng L, Liao D, Liu X, Ma Y, Liu C, Li S, Ruan H, Lei X, Wang X, Zhang Z. Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome. J Med Chem. 2016 Dec 19. [Epub ahead of print] PubMed PMID: 27992216. |
