For research use only, not for therapeutic use.
Ripasudil(cas 887375-67-9) is an inhibitor of Rho-associated protein kinase (ROCK; IC50s = 51 and 19 nM for ROCK-I and ROCK-II, respectively). Formulations containing ripasudil are used to lower intraocular pressure in the context of glaucoma and ocular hypertension.<span></span>
Catalog Number | A000100 |
CAS Number | 887375-67-9 |
Synonyms | Isoquinoline, 4-​fluoro-​5-​[[(2S)​-​hexahydro-​2-​methyl-​1H-​1,​4-​diazepin-​1-​yl]​sulfonyl]​-​, hydrochloride, hydrate (1:1:2) |
Molecular Formula | C15H18FN3O2S • HCl [2H2O] |
Purity | ≥95% |
Target | Rho |
Solubility | Soluble in DMSO |
Storage | Store at -20°C |
InChIKey | CMDJNMACGABCKQ-XVSRHIFFSA-N |
SMILES | FC1=C2C(C=CC=C2S(N3CCCNC[C@@H]3C)(=O)=O)=CN=C1.Cl.O.O |
Reference | 1: Isobe T, Ohta M, Kaneko Y, Kawai H. Species differences in metabolism of 2: Nakabayashi S, Kawai M, Yoshioka T, Song YS, Tani T, Yoshida A, Nagaoka T. </br> </br> |