RIPGBM

• CAT Number: I019303
• CAS Number: 355406-76-7
• Molecular Formula: C₂₆H₂₁FN₂O₃
• Molecular Weight: 428.45
• Purity: ≥95%
• Target: Apoptosis
• IUPAC Name: N-[3-(benzylamino)-1,4-dioxonaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide
• InChI: 1S/C26H21FN2O3/c1-17(30)29(16-19-11-13-20(27)14-12-19)24-23(28-15-18-7-3-2-4-8-18)25(31)21-9-5-6-10-22(21)26(24)32/h2-14,28H,15-16H2,1H3
• InChIKey: COATXBHZYVUJQP-UHFFFAOYSA-N
• SMILES: CC(=O)N(CC1=CC=C(C=C1)F)C2=C(C(=O)C3=CC=CC=C3C2=O)NCC4=CC=CC=C4

RIPGBM(CAT: I019303) is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM. It exerts its apoptotic effect by binding to receptor-interacting protein kinase 2 (RIPK2) and functioning as a molecular switch. This leads to a reduction in the formation of a prosurvival RIPK2/TAK1 complex and an increase in the formation of a proapoptotic RIPK2/caspase 1 complex.