RIPGBM

• CAT Number: I019303
• CAS Number: 355406-76-7
• Molecular Formula: C₂₆H₂₁FN₂O₃
• Molecular Weight: 428.45
• Purity: ≥95%
• Target: Apoptosis

RIPGBM(CAT: I019303) is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM. It exerts its apoptotic effect by binding to receptor-interacting protein kinase 2 (RIPK2) and functioning as a molecular switch. This leads to a reduction in the formation of a prosurvival RIPK2/TAK1 complex and an increase in the formation of a proapoptotic RIPK2/caspase 1 complex.

Reference

[1]. Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.