RIPK1-IN-4

• CAT Number: I018276
• CAS Number: 1481641-08-0
• Molecular Formula: C₂₃H₂₃N₅O₂
• Molecular Weight: 401.46
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea
• InChI: InChI=1S/C23H23N5O2/c1-23(2,3)19-13-20(28-30-19)27-22(29)26-15-9-7-14(8-10-15)16-5-4-6-18-17(16)11-12-25-21(18)24/h4-13H,1-3H3,(H2,24,25)(H2,26,27,28,29)
• InChIKey: SLRYMOUSQMDJPH-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CC=CC4=C3C=CN=C4N

RIPK1-IN-4 (Cat No.:I018276) is a potent type II kinase receptor-interacting protein 1 (RIP1) kinase inhibitor and binds to the DL1-out inactive form of RIP1, for RIP1 and ADP- Glo kinase with IC50 of 16 nM and 10 nM, respectively. If you need, please contact us in time, and we will reply as soon as possible within 24 hours.

Reference

[1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.