For research use only. Not for therapeutic Use.
RIPK1-IN-7 (Cat.No:I019038) is a small molecule inhibitor designed to selectively target RIPK1 (Receptor Interacting Protein Kinase 1), a key regulator in cell death and inflammation pathways. RIPK1 is involved in necroptosis, a form of programmed cell death, and its dysregulation is associated with various inflammatory diseases and neurodegenerative conditions. RIPK1-IN-7 has shown promise in preclinical studies for reducing inflammation and preventing tissue damage in conditions like autoimmune diseases, ischemia, and neuroinflammation. Further research is ongoing to evaluate its therapeutic potential.
| Catalog Number | I019038 |
| CAS Number | 2300982-44-7 |
| Molecular Formula | C₂₅H₂₂F₃N₅O₂ |
| Purity | ≥95% |
| Target | RIP kinase |
| IUPAC Name | 1-[5-(4-amino-7-ethylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethoxy)phenyl]ethanone |
| InChI | 1S/C25H22F3N5O2/c1-2-32-13-19(22-23(29)30-14-31-24(22)32)16-6-7-20-17(12-16)8-9-33(20)21(34)11-15-4-3-5-18(10-15)35-25(26,27)28/h3-7,10,12-14H,2,8-9,11H2,1H3,(H2,29,30,31) |
| InChIKey | APPXQUDJLJXULP-UHFFFAOYSA-N |
| SMILES | CCN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)OC(F)(F)F |
| Reference | [1]. Li Y, et al. Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. J Med Chem. 2018 Dec 27;61(24):11398-11414. |
