RITA

• CAT Number: I002641
• CAS Number: 213261-59-7
• Molecular Formula: C14H12O3S2
• Molecular Weight: 292.37
• Purity: ≥95%
• Synonyms: [5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
• Target: Autophagy
• Solubility: DMSO 58mg/mL; Water <1 mg/mL; Ethanol 8 mg/mL
• Storage: store at -20℃
• IC50: 54nM in MCF-7 cells
• InChI: InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2
• InChIKey: KZENBFUSKMWCJF-UHFFFAOYSA-N
• SMILES: OCc1ccc(s1)c1ccc(o1)c1ccc(CO)s1

RITA(CAT: I002641) is a small molecule compound that selectively activates the tumor-suppressor protein p53 by disrupting its interaction with MDM2, a negative regulator. This reactivation of p53 leads to cell cycle arrest and apoptosis in cancer cells, making RITA a promising anticancer agent. It has been studied for its potential to treat various cancers by restoring p53 function, which is often compromised in tumor cells due to mutations or MDM2 overexpression.