For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Ritodrine HCl is a β-2 adrenergic receptor agonist.<br>Target: β-2 Adrenergic Receptor<br>Ritodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCTs for different gestational ages and different labour stages should be designed for further study [1]. Ritodrine is a beta-2 adrenergic receptor agonist – a class of medication used for smooth muscle relaxation. Since ritodrine has a bulky N-substituent, it has high β2-selectivity. Also, the 4/’-hydroxy on the benzene ring is important for activity as it is needed to form hydrogen bonds. However, the 4/’-hydroxy makes it susceptible to metabolism by COMT. Since it is β2-selective it is used for premature labor [2].<br></p>
| Catalog Number | I002771 |
| CAS Number | 23239-51-2 |
| Synonyms | 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol;hydrochloride |
| Molecular Formula | C17H21NO3.HCl |
| Purity | ≥95% |
| Target | Adrenergic Receptor |
| Solubility | DMSO 65 mg/mL; Water 65 mg/mL |
| Storage | 3 years -20C powder |
| Reference | </br>1:The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children/’s Study. Kawanishi Y, Saijo Y, Yoshioka E, Nakagi Y, Yoshida T, Miyamoto T, Sengoku K, Ito Y, Miyashita C, Araki A, Kishi R.PLoS One. 2016 Jun 27;11(6):e0158155. doi: 10.1371/journal.pone.0158155. eCollection 2016. PMID: 27348869 Free PMC Article</br>2:In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. Onishi H, Sakata O, Yumoto K.Biol Pharm Bull. 2015;38(6):919-25. doi: 10.1248/bpb.b14-00833. PMID: 26027834 Free Article</br>3:In vivo absorption study of ritodrine hydrochloride in the buccal administration to rats. Sakata O, Onishi H.Drug Dev Ind Pharm. 2013 Sep;39(9):1414-20. doi: 10.3109/03639045.2012.704044. Epub 2012 Jul 10. PMID: 22779426 </br>4:Agranulocytosis associated with intravenous ritodrine hydrochloride therapy: two case reports by different mechanisms. Yasuda R, Makino Y, Matsuda Y, Kawamichi Y, Matsui H.J Obstet Gynaecol Res. 2012 Mar;38(3):574-7. doi: 10.1111/j.1447-0756.2011.01756.x. Epub 2012 Feb 22. PMID: 22353036 </br>5:Rhabdomyolysis caused by tocolytic therapy with oral ritodrine hydrochloride in a pregnant woman with placenta previa: Is this a rare case with a latent predisposing condition? Matsubara S, Muramatsu S.J Obstet Gynaecol Res. 2011 Jun;37(6):672. doi: 10.1111/j.1447-0756.2011.01613.x. Epub 2011 Apr 26. No abstract available. PMID: 21518138 </br>6:Rhabdomyolysis caused by tocolytic therapy with oral ritodrine hydrochloride in a pregnant woman with placenta previa. Nakajima Y, Masaoka N, Tsuduki Y, Honda N, Sakai M.J Obstet Gynaecol Res. 2011 Jun;37(6):629-32. doi: 10.1111/j.1447-0756.2010.01403.x. Epub 2010 Dec 15. PMID: 21159044 </br>7:Pharmacokinetics and pharmacodynamics of ritodrine hydrochloride administered orally and intramuscularly to female healthy volunteers. Marzo A, Coa K, Fontana E, Tavazzi S, Bo LD, Ismaili S, Zava D, Cantoni V, Bertolini A.Arzneimittelforschung. 2010;60(8):510-8. doi: 10.1055/s-0031-1296320. PMID: 20863008 </br>8:[A suspected case of acute respiratory failure caused by ritodrine hydrochloride]. Urabe K, Mukae H, Sakamoto N, Nakashima S, Izumikawa K, Ishimatsu Y, Ikeda S, Kohno S.Nihon Kokyuki Gakkai Zasshi. 2010 Jul;48(7):520-3. Japanese. PMID: 20684217 </br>9:Erythematous and bullous rash strongly indicating toxic epidermal necrolysis associated with the use of intravenous ritodrine hydrochloride. Shiba M, Kido K, Umezawa K, Higaki H, Matsumoto S, Taguchi A, Hayashi T, Higaki Y, Sasamori Y, Shinozuka N, Fuse Y, Kikuchi A, Ayabe T.J Obstet Gynaecol Res. 2010 Jun;36(3):676-80. doi: 10.1111/j.1447-0756.2010.01173.x. PMID: 20598056 </br>10:Rhabdomyolysis caused by tocolytic therapy with ritodrine hydrochloride. Verriello L, D/’Amico D, Pauletto G, Gigli GL, Bergonzi P.Neuromuscul Disord. 2009 Oct;19(10):718-20. doi: 10.1016/j.nmd.2009.06.364. Epub 2009 Jun 24. PMID: 19556131 |
