RL-6-Me-7-OH

• CAT Number: I040165
• CAS Number: 2184-54-5
• Molecular Formula: C12H16N4O7
• Molecular Weight: 328.28
• Purity: ≥95%
• Synonyms: 6-methyl-8-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-1H-pteridine-2,4,7-trione
• InChI: InChI=1S/C12H16N4O7/c1-4-11(22)16(2-5(18)8(20)6(19)3-17)9-7(13-4)10(21)15-12(23)14-9/h5-6,8,17-20H,2-3H2,1H3,(H2,14,15,21,23)/t5-,6+,8-/m0/s1
• InChIKey: QCYVUUAIJUUUPI-BBVRLYRLSA-N
• SMILES: CC1=NC2=C(NC(=O)NC2=O)N(C1=O)CC(C(C(CO)O)O)O

RL-6-Me-7-OH is a hapten that activates human and mouse MAIT cells (EC50=25µM). RL-6-Me-7-OH can be combined with carrier proteins and used in antigen design. RL-6-Me-7-OH can be used in inflammation and immunity research[1].

Reference

[1]. Corbett AJ, et al. Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries. Front Immunol. 2020 Aug 27;11:1961.
 [Content Brief]