RL648_81

• CAT Number: I035619
• CAS Number: 1919050-87-5
• Molecular Formula: C17H17F4N3O2
• Molecular Weight: 371.33
• Purity: 98%
• Synonyms: RL648_81
• Target: Potassium Channel
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: -20 °C
• IUPAC Name: Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate
• InChI: InChI=1S/C17H17F4N3O2/c1-2-26-16(25)24-13-8-7-12(14(18)15(13)22)23-9-10-3-5-11(6-4-10)17(19,20)21/h3-8,23H,2,9,22H2,1H3,(H,24,25)
• InChIKey: MVSMZQRRMPUGHI-UHFFFAOYSA-N
• SMILES: O=C(OCC)NC1=CC=C(NCC2=CC=C(C(F)(F)F)C=C2)C(F)=C1N

RL648_81（Cat No.:I035619） is a newly developed compound known for its potent and selective activation of KCNQ2/3 channels. These channels play a crucial role in regulating the electrical activity of neurons. By specifically targeting and activating KCNQ2/3 channels, RL648_81 has the potential to modulate neuronal excitability and synaptic transmission. This unique property makes it a promising candidate for the treatment of neurological disorders characterized by abnormal neuronal activity, such as epilepsy.

Reference

1: Kumar M, Reed N, Liu R, Aizenman E, Wipf P, Tzounopoulos T. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77. doi: 10.1124/mol.115.103200. Epub 2016 Mar 22. PubMed PMID: 27005699.