For research use only. Not for therapeutic Use.
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM[1].
| Catalog Number | I009055 |
| CAS Number | 1024448-59-6 |
| Synonyms | 1-benzyl-4-(4-chloro-2-nitrophenyl)sulfonylpiperazine |
| Molecular Formula | C17H18ClN3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2 |
| InChIKey | ZNLVYSJQUMALEO-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CC2=CC=CC=C2)S(=O)(=O)C3=C(C=C(C=C3)Cl)[N+](=O)[O-] |
| Reference | [1]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4. |
