RN-18

• CAT Number: I012005
• CAS Number: 431980-38-0
• Molecular Formula: C20H16N2O4S
• Molecular Weight: 380.42
• Purity: ≥95%
• Synonyms: RN-18; RN 18; RN18.;N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-benzamide
• Target: HIV
• Solubility: Soluble in DMSO
• Storage: Store at 0-8 °C
• IUPAC Name: N-(2-methoxyphenyl)-2-(4-nitrophenyl)sulfanylbenzamide
• InChI: InChI=1S/C20H16N2O4S/c1-26-18-8-4-3-7-17(18)21-20(23)16-6-2-5-9-19(16)27-15-12-10-14(11-13-15)22(24)25/h2-13H,1H3,(H,21,23)
• InChIKey: JKNUDHUHXMELIJ-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1NC(=O)C2=CC=CC=C2SC3=CC=C(C=C3)[N+](=O)[O-]

RN-18（Cat No.:I012005）is a potent, selective inhibitor of receptor activator of nuclear factor kappa-Β ligand (RANKL), crucial in osteoclastogenesis and bone resorption. By targeting the RANK-RANKL signaling pathway, RN-18 has potential therapeutic applications in conditions such as osteoporosis, rheumatoid arthritis, and other inflammatory bone diseases. It prevents the activation of osteoclasts, thereby inhibiting bone degradation and preserving bone density. This selective action makes RN-18 a valuable tool for exploring treatments aimed at reducing bone loss and enhancing bone health in various pathological conditions.