RN-9893

• CAT Number: I011270
• CAS Number: 1803003-68-0(HCl salt)
• Molecular Formula: C21H23F3N4O5S
• Molecular Weight: 500.49
• Purity: ≥95%
• Synonyms: 2-nitro-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamide
• InChI: InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
• InChIKey: KORKKQLDGMHNKO-UHFFFAOYSA-N
• SMILES: CC(C)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]

RN-9893(CAT: I011270) is a potent and selective antagonist of the TRPV4 (transient receptor potential vanilloid 4) ion channel, with IC₅₀ values of 320 nM (mouse), 420 nM (human), and 660 nM (rat). TRPV4 is involved in various physiological processes, including osmoregulation, mechanosensation, and inflammatory responses. By inhibiting TRPV4 activity, RN-9893 serves as a valuable research tool for studying its role in pain, pulmonary edema, cardiovascular dysfunction, and neuroinflammation. Its species-selective potency and high specificity make RN-9893 suitable for in vitro and in vivo models, supporting the development of TRPV4-targeted therapies for inflammatory and sensory-related disorders.