RN-9893

For research use only. Not for therapeutic Use.

  • CAT Number: I011270
  • CAS Number: 1803003-68-0
  • Molecular Formula: C21H23F3N4O5S
  • Molecular Weight: 500.49
  • Purity: ≥95%
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RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively[1].


Catalog Number I011270
CAS Number 1803003-68-0
Synonyms

2-nitro-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamide

Molecular Formula C21H23F3N4O5S
Purity ≥95%
InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
InChIKey KORKKQLDGMHNKO-UHFFFAOYSA-N
SMILES CC(C)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]
Reference

[1]. Wei ZL, et, al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.

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