For research use only. Not for therapeutic Use.
RNase L-IN-1 Trihydrochloride (Cat No.: I040041) is a potent inhibitor of RNase L, an endoribonuclease involved in the antiviral innate immune response. By blocking RNase L activity, it prevents RNA degradation and modulates interferon-mediated pathways, making it a valuable tool in infection disease and immunology research. The trihydrochloride form enhances solubility and stability for in vitro and in vivo applications. RNase L-IN-1 is widely used to study antiviral defense mechanisms, RNA metabolism, and potential therapeutic strategies for viral infections and immune disorders.
| Synonyms | 5-[(E)-[4-(2-aminoethylcarbamoyl)-5-(3-fluorophenyl)imino-3-hydroxythiophen-2-ylidene]methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;trihydrochloride |
| Molecular Formula | C27H38Cl3FN6O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C27H35FN6O3S.3ClH/c1-5-34(6-2)13-12-31-25(36)22-16(3)20(32-17(22)4)15-21-24(35)23(26(37)30-11-10-29)27(38-21)33-19-9-7-8-18(28)14-19;;;/h7-9,14-15,32,35H,5-6,10-13,29H2,1-4H3,(H,30,37)(H,31,36);3*1H/b21-15+,33-27?;;; |
| InChIKey | DQRHHNTUBHYOBP-XRRPWJDQSA-N |
| SMILES | CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C(=C(C(=NC3=CC(=CC=C3)F)S2)C(=O)NCCN)O)C.Cl.Cl.Cl |
| Reference | [1]. Hwang J, et al. Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors. Eur J Med Chem. 2023 Aug 5;256:115439. |
