RNF5 inhibitor inh-02

• CAT Number: I035641
• CAS Number: 324579-65-9
• Molecular Formula: C23H20N4S
• Molecular Weight: 384.50
• Purity: ≥95%
• Synonyms: N-(4-benzyl-3-methyl-1,2,4-thiadiazol-5-ylidene)-N’-phenylbenzenecarboximidamide
• InChI: InChI=1S/C23H20N4S/c1-18-26-28-23(27(18)17-19-11-5-2-6-12-19)25-22(20-13-7-3-8-14-20)24-21-15-9-4-10-16-21/h2-16H,17H2,1H3
• InChIKey: FYZFQLYZABRFAZ-UHFFFAOYSA-N
• SMILES: CC1=NSC(=NC(=NC2=CC=CC=C2)C3=CC=CC=C3)N1CC4=CC=CC=C4

RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research[1].

Reference

[1]. Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8.
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