For research use only. Not for therapeutic Use.
Ro20-1724 (Cat.No:I009102) is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM)
| Catalog Number | I009102 |
| CAS Number | 29925-17-5 |
| Synonyms | Ro20-1724; Ro 20-1724; Ro-20-1724.;4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one |
| Molecular Formula | C15H22N2O3 |
| Purity | ≥95% |
| Target | Phosphodiesterase (PDE) |
| Solubility | Soluble in DMSO |
| Storage | Store at RT |
| IUPAC Name | 4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one |
| InChI | InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) |
| InChIKey | PDMUULPVBYQBBK-UHFFFAOYSA-N |
| SMILES | CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC |
| Reference | </br>1:Chronic exposure to Ro20-1724 protects dopaminergic neurons in vitro against the neurotoxic action of N-methyl-D-aspartate and 1-methyl-4-phenylpyridinium. Dickie BG, Greenfield SA.Brain Res. 1997 Apr 11;753(2):335-9. PMID: 9125421 </br>2:Effects of cyclic nucleotide phosphodiesterase IV inhibitor, Ro20,1724, on pancreatic exocrine secretion in dog. Iwatsuki K, Ren LM, Chiba S.Clin Exp Pharmacol Physiol. 1994 Sep;21(9):701-7. PMID: 7529665 </br>3:The synthesis and degradation of poly(a)-containing mRNAs in mouse neuroblastoma cells treated with dibutyryl cAMP or with Ro20-1724. Morrison MR, Hall CL, Pardue S, Brodeur R, Baskin F, Rosenberg RN.J Neurochem. 1980 Jan;34(1):50-8. No abstract available. PMID: 6108985 |
