RO 25-6981 hydrochloride

• CAT Number: I047523
• CAS Number: 919289-58-0
• Molecular Formula: C22H29NO2.HCl
• Molecular Weight: 375.93
• Purity: ≥95%
• IUPAC Name: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;hydrochloride
• InChI: InChI=1S/C22H29NO2.ClH/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H/t17-,22+;/m0./s1
• SMILES: C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.Cl

Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit; Optimal salt form, which is more water soluble than its maleate salt form (Axon 2601)
KEYWORDS: RO 25-6981 hydrochloride | Supplier | NR2B antagonist | RO25-6981 HCl | CAS [1312991-76-6] | [169274-78-6] | Glutamate | NMDA | Antagonist | Ion Channel

Reference

G Fischer et al.  Ro 25-6981, a highly potent and selective blocker of N-Methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J. Pharmacol. Exp. Ther. 1997, 283, 1285.