Ro 25-6981

• CAT Number: I002207
• CAS Number: 169274-78-6
• Molecular Formula: C22H29NO2
• Molecular Weight: 339.47
• Purity: ≥95%
• Synonyms: 4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl)phenol
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 9 nM [1]
• IUPAC Name: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
• InChI: InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
• InChIKey: WVZSEUPGUDIELE-HTAPYJJXSA-N
• SMILES: C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O

Ro 25-6981(CAT: I002207) is a potent and selective antagonist of the NMDA receptor containing the NR2B subunit, widely utilized in neuroscience research. By specifically targeting NR2B-containing NMDA receptors, it modulates excitatory neurotransmission, synaptic plasticity, and neurodegenerative processes. This compound is extensively studied in the context of conditions such as chronic pain, depression, and neurodegenerative diseases like Alzheimer’s disease. With its high selectivity and efficacy, Ro 25-6981 is ideal for in vitro and in vivo studies, providing insights into NMDA receptor-mediated signaling pathways and supporting the development of targeted therapies for neurological disorders.