Ro 25-6981 maleate

• CAT Number: I009118
• CAS Number: 1312991-76-6 (maleate); 169274-78-6 (free base)
• Molecular Formula: C26H33NO6
• Molecular Weight: 455.55
• Purity: ≥95%
• Synonyms: Ro 25-6981; Ro25-6981; Ro-25-6981; Ro-256981; Ro 256981; Ro256981; Ro 25-6981 maleate;4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl)phenol maleate
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;(Z)-but-2-enedioic acid
• InChI: InChI=1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h2-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
• InChIKey: FYJZEHCQSUBZDY-SEELMCCHSA-N
• SMILES: C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.C(=C\C(=O)O)\C(=O)O

Ro 25-6981 maleate（Cat No.:I009118）is a selective antagonist of the NMDA (N-methyl-D-aspartate) receptor, specifically targeting the NR2B subunit. It is primarily used in preclinical research to investigate the role of NMDA receptors in synaptic plasticity, neurodegenerative diseases, and pain management. By blocking the NR2B subunit, Ro 25-6981 maleate can modulate glutamatergic neurotransmission, which is implicated in conditions like Alzheimer’s disease, Parkinson’s disease, and chronic pain. Ro 25-6981 has potential therapeutic applications in conditions involving excessive NMDA receptor activity, though it is not yet approved for clinical use.

Reference

1: Szczurowska E, Mareš P. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. doi: 10.1016/j.brainresbull.2014.11.001. Epub 2014 Nov 11. PubMed PMID: 25446739.2:Jiang M, Zhang W, Ma Z, Gu X. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63. doi: 10.1016/j.pbb.2013.09.007. Epub 2013 Sep 27. PubMed PMID: 24076088.3:Soloviova OA, Proshin AT, Storozheva ZI, Sherstnev VV. Neurogenesis enhancer RO 25-6981 facilitates repeated spatial learning in adult rats. Bull Exp Biol Med. 2012 Sep;153(5):764-6. PubMed PMID: 23113280.