Ro 3-1314

• CAT Number: I011560
• CAS Number: 2012-14-8
• Molecular Formula: C18H28O2
• Molecular Weight: 276.41
• Purity: ≥95%
• Synonyms: octadeca-9,12-diynoic acid
• InChI: InChI=1S/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-5,8,11-17H2,1H3,(H,19,20)
• InChIKey: KDYILQLPKVZDGB-UHFFFAOYSA-N
• SMILES: CCCCCC#CCC#CCCCCCCCC(=O)O

Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments[1].

Reference

[1]. M Hitchcock, et al. Arachidonic acid metabolism and modulation of in vitro anaphylaxis by 5,8,11,14-eicosatetraynoic acid and 9a,12a-octadecadiynoic acid. Br J Pharmacol. 1981 Apr;72(4):689-95.
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