For research use only. Not for therapeutic Use.
Ro-3306（Cat No.:I013860）is a potent and selective inhibitor of cyclin-dependent kinase 1 (CDK1), an enzyme critical for cell cycle progression, particularly during the G2/M transition. By inhibiting CDK1 activity, Ro-3306 effectively arrests cells in the G2 phase, preventing mitosis and providing a tool for studying cell cycle regulation. It is widely used in research for understanding the mechanisms of cell division and for investigating cancer biology, as many tumors rely on CDK1 for uncontrolled proliferation. Ro-3306 has potential therapeutic implications, especially in cancer treatment.
| Catalog Number | I013860 |
| CAS Number | 872573-93-8 |
| Molecular Formula | C₁₈H₁₃N₃OS₂ |
| Purity | ≥95% |
| Target | CDK |
| Solubility | DMSO: ≥ 47 mg/mL |
| IUPAC Name | (5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylimino)-1,3-thiazolidin-4-one |
| InChI | InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10- |
| InChIKey | XOLMRFUGOINFDQ-YBEGLDIGSA-N |
| SMILES | C1=CC2=C(C=CC(=C2)/C=C\3/C(=O)NC(=NCC4=CC=CS4)S3)N=C1 |
| Reference | [1]. Vassilev LT, et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5.<br>[2]. Kojima K, et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009 Jun;100(6):1128-36.<br>[3]. Jang WI, et al. A specific inhibitor of CDK1, RO-3306, reversibly arrests meiosis during in vitro maturation of porcine oocytes. Anim Reprod Sci. 2014 Jan 30;144(3-4):102-8. |
