Ro 46-2005（Cat No.:I001867）is a potent and selective antagonist of the cysteinyl leukotriene receptor 1 (CysLT1). It is primarily used in research focused on understanding the role of leukotrienes in inflammatory processes, including asthma and allergic reactions. By blocking the CysLT1 receptor, Ro 46-2005 inhibits leukotriene-induced bronchoconstriction, offering insights into therapeutic interventions for respiratory diseases. Its high specificity and affinity for the receptor make it a valuable tool for studies targeting the leukotriene pathway, contributing to advancements in anti-inflammatory drug development.
| Catalog Number | I001867 |
| CAS Number | 150725-87-4 |
| Molecular Formula | C23H27N3O6S |
| Purity | ≥95% |
| Target | Endothelin |
| Solubility | DMSO: ≥ 28 mg/mL |
| Storage | Desiccate at RT |
| IC50 | 220 nM (ETA) |
| IUPAC Name | 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide |
| InChI | InChI=1S/C23H27N3O6S/c1-23(2,3)16-8-10-19(11-9-16)33(28,29)26-21-20(22(25-15-24-21)31-13-12-27)32-18-7-5-6-17(14-18)30-4/h5-11,14-15,27H,12-13H2,1-4H3,(H,24,25,26) |
| InChIKey | ZNXOKLWCOWOECF-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC=N2)OCCO)OC3=CC=CC(=C3)OC |
| Reference | </br>1:Characterisation of the endothelin receptor mediating contraction of human pulmonary artery using BQ123 and Ro 46-2005. Buchan KW, Magnusson H, Rabe KF, Sumner MJ, Watts IS.Eur J Pharmacol. 1994 Aug 1;260(2-3):221-6. PMID: 7988646 </br>2:Comparison of PD 145065 and Ro 46-2005 as antagonists of contractions of guinea-pig airways induced by endothelin-1 or IRL 1620. Battistini B, Warner TD, Fournier A, Vane JR.Eur J Pharmacol. 1994 Feb 11;252(3):341-5. PMID: 8162956 </br>3:In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors. Breu V, Löffler BM, Clozel M.FEBS Lett. 1993 Nov 15;334(2):210-4. PMID: 8224248 Free Article</br>4:Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma. Löffler BM, Breu V, Clozel M.FEBS Lett. 1993 Oct 25;333(1-2):108-10. PMID: 8224145 Free Article</br>5:In vivo pharmacology of Ro 46-2005, the first synthetic nonpeptide endothelin receptor antagonist: implications for endothelin physiology. Clozel M, Breu V, Gray GA, Löffler BM.J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9. PMID: 7509992 |
