Ro 5-3335

• CAT Number: I011003
• CAS Number: 30195-30-3
• Molecular Formula: C13H10ClN3O
• Molecular Weight: 259.693
• Purity: ≥95%
• Synonyms: Alternative Name: CBFβ-Runx1 inhibitor II
• Target: Transcription Factors
• Solubility: Soluble to 100 mM in DMSO
• Storage: Store at +4C
• IUPAC Name: 7-chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-one
• InChI: InChI=1S/C13H10ClN3O/c14-8-3-4-10-9(6-8)13(11-2-1-5-15-11)16-7-12(18)17-10/h1-6,15H,7H2,(H,17,18)
• InChIKey: XWNMORIHKRROGW-UHFFFAOYSA-N
• SMILES: C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CN3

Core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro.