RO5256390 HCl

• CAT Number: I009161
• CAS Number: 1043495-96-0 (free base)
• Molecular Formula: C13H20Cl2N2O
• Molecular Weight: 291.216
• Purity: ≥95%
• Synonyms: RO5256390; RO-5256390; RO 5256390.;(S)-4-((S)-2-phenylbutyl)-4,5-dihydrooxazol-2-amine dihydrochloride
• Target: Trace Amine-associated Receptor (TAAR)
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• SMILES: NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1.[H]Cl.[H]Cl

RO5256390 HCl (Cat No.: I009161) is a selective and brain-penetrant trace amine-associated receptor 1 (TAAR1) agonist, developed for use in neuropsychiatric and cognitive disorder research. By activating TAAR1, RO5256390 HCl modulates dopaminergic and serotonergic neurotransmission, showing potential in treating conditions such as schizophrenia, depression, and addiction. It exhibits favorable pharmacokinetics, central nervous system selectivity, and minimal off-target effects. RO5256390 HCl is a valuable research tool for exploring TAAR1 signaling pathways and developing novel therapies targeting neurochemical imbalances in mental health disorders.

Reference

1:Pei Y, Mortas P, Hoener MC, Canales JJ. Selective activation of the trace amine-associated receptor 1 decreases cocaine/’s reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015 Jun 3. PubMed PMID: 26048337.2:Pei Y, Lee J, Leo D, Gainetdinov RR, Hoener MC, Canales JJ. Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology. 2014 Sep;39(10):2299-308. doi: 10.1038/npp.2014.88. Epub 2014 Apr 11. PubMed PMID: 24722355; PubMed Central PMCID: PMC4138750.