For research use only. Not for therapeutic Use.
RO5256390 is a TAAR1 agonist. RO5256390 blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties. TAAR1 activation promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models. TAAR1 agonists may provide a novel and differentiated treatment of schizophrenia as compared with current medication standards: TAAR1 agonists may improve not only the positive symptoms but also the negative symptoms and cognitive deficits, without causing adverse effects such as motor impairments or weight gain.
| Catalog Number | I009161 |
| CAS Number | 1043495-96-0 (free base) |
| Synonyms | RO5256390; RO-5256390; RO 5256390.;(S)-4-((S)-2-phenylbutyl)-4,5-dihydrooxazol-2-amine dihydrochloride |
| Molecular Formula | C13H20Cl2N2O |
| Purity | ≥95% |
| Target | Trace Amine-associated Receptor (TAAR) |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| SMILES | NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1.[H]Cl.[H]Cl |
| Reference | </br>1:Pei Y, Mortas P, Hoener MC, Canales JJ. Selective activation of the trace amine-associated receptor 1 decreases cocaine/’s reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015 Jun 3. PubMed PMID: 26048337.</br>2:Pei Y, Lee J, Leo D, Gainetdinov RR, Hoener MC, Canales JJ. Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology. 2014 Sep;39(10):2299-308. doi: 10.1038/npp.2014.88. Epub 2014 Apr 11. PubMed PMID: 24722355; PubMed Central PMCID: PMC4138750. |
