ROC-325

• CAT Number: I008822
• CAS Number: 1859141-26-6
• Molecular Formula: C28H27ClN4OS
• Molecular Weight: 503.06
• Purity: ≥95%
• Synonyms: ROC-325; ROC 325; ROC325.;1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
• Target: Apoptosis
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C28H27ClN4OS/c1-18-7-10-23(26-27(34)21-5-3-4-6-25(21)35-28(18)26)32-14-16-33(2)15-13-31-22-11-12-30-24-17-19(29)8-9-20(22)24/h3-12,17,32H,13-16H2,1-2H3,(H,30,31)
• InChIKey: HXUYKEGAEIYPKY-UHFFFAOYSA-N
• SMILES: O=C1C2=C(C(C)=CC=C2NCCN(C)CCNC3=C(C=CC(Cl)=C4)C4=NC=C3)SC5=CC=CC=C51

ROC-325(CAT: I008822) is an autophagy inhibitor that has shown promising effects as an anticancer agent. In in vitro studies, ROC-325 has demonstrated superior anticancer effects compared to hydroxychloroquine (HCQ), an existing autophagy inhibitor, across 12 different cancer cell lines with diverse genetic backgrounds. ROC-325 specifically antagonizes the growth and survival of renal cell carcinoma (RCC) in a manner dependent on the ATG5/7 proteins, which are crucial for the autophagy process. Additionally, ROC-325 induces apoptosis and exhibits favorable selectivity, further supporting its potential as an effective therapeutic agent.