For research use only. Not for therapeutic Use.
ROCK-IN-D2 is a high-purity, deuterated compound designed for cutting-edge pharmaceutical research. Containing two deuterium atoms, it enhances stability and precision in pharmacokinetic studies and biochemical research. This isotopically labeled compound is crucial for investigating Rho-associated protein kinase (ROCK) pathways, providing accurate and reliable analytical results. Ideal for researchers exploring innovative treatments in cardiovascular and neurological disorders, ROCK-IN-D2 is a valuable tool for advanced scientific investigations. Enhance your research quality with this essential and robust compound.
Catalog Number | I035659 |
CAS Number | 1219721-78-4 |
Synonyms | ROCK-IN-D2; ROCK IN D2; ROCKIND2; ROCK inhibitor D2; ROCK-inhibitor-D2; |
Molecular Formula | C22H28N6O |
Purity | 98% |
Target | TGF-beta/Smad |
Solubility | Soluble in DMSO |
Appearance | Solid powder |
Storage | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
IUPAC Name | 1-benzyl-3-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-(1H-pyrazol-4-yl)phenyl)urea |
InChI | InChI=1S/C22H28N6O/c1-27(2)11-12-28(3)21-13-18(19-15-24-25-16-19)9-10-20(21)26-22(29)23-14-17-7-5-4-6-8-17/h4-10,13,15-16H,11-12,14H2,1-3H3,(H,24,25)(H2,23,26,29) |
InChIKey | UBZZFFAVFOEUFI-UHFFFAOYSA-N |
SMILES | O=C(NC1=C(N(CCN(C)C)C)C=C(C2=CNN=C2)C=C1)NCC3=CC=CC=C3 |
Reference | 1: Foti RS, Pearson JT, Wong SL, Zalikowski JA, Boudreaux MD, Prokop SP, Davis JA, Banfield C, Emery MG, Rock DA, Wahlstrom JL, Wienkers LC, Amore BM. Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors. Drug Metab Dispos. 2012 Dec;40(12):2239-49. doi: 10.1124/dmd.112.047928. Epub 2012 Aug 28. PubMed PMID: 22930276. |