ROCK-IN-D2

For research use only. Not for therapeutic Use.

  • CAT Number: I035659
  • CAS Number: 1219721-78-4
  • Molecular Formula: C22H28N6O
  • Molecular Weight: 392.5
  • Purity: 98%
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ROCK-IN-D2 is a high-purity, deuterated compound designed for cutting-edge pharmaceutical research. Containing two deuterium atoms, it enhances stability and precision in pharmacokinetic studies and biochemical research. This isotopically labeled compound is crucial for investigating Rho-associated protein kinase (ROCK) pathways, providing accurate and reliable analytical results. Ideal for researchers exploring innovative treatments in cardiovascular and neurological disorders, ROCK-IN-D2 is a valuable tool for advanced scientific investigations. Enhance your research quality with this essential and robust compound.


Catalog Number I035659
CAS Number 1219721-78-4
Synonyms

ROCK-IN-D2; ROCK IN D2; ROCKIND2; ROCK inhibitor D2; ROCK-inhibitor-D2;

Molecular Formula C22H28N6O
Purity 98%
Target TGF-beta/Smad
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
IUPAC Name 1-benzyl-3-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-(1H-pyrazol-4-yl)phenyl)urea
InChI InChI=1S/C22H28N6O/c1-27(2)11-12-28(3)21-13-18(19-15-24-25-16-19)9-10-20(21)26-22(29)23-14-17-7-5-4-6-8-17/h4-10,13,15-16H,11-12,14H2,1-3H3,(H,24,25)(H2,23,26,29)
InChIKey UBZZFFAVFOEUFI-UHFFFAOYSA-N
SMILES O=C(NC1=C(N(CCN(C)C)C)C=C(C2=CNN=C2)C=C1)NCC3=CC=CC=C3
Reference

1: Foti RS, Pearson JT, Wong SL, Zalikowski JA, Boudreaux MD, Prokop SP, Davis JA, Banfield C, Emery MG, Rock DA, Wahlstrom JL, Wienkers LC, Amore BM. Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors. Drug Metab Dispos. 2012 Dec;40(12):2239-49. doi: 10.1124/dmd.112.047928. Epub 2012 Aug 28. PubMed PMID: 22930276.
2: Choi HJ, Han JS. Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells. Biochim Biophys Acta. 2012 Jun;1823(6):1082-91. doi: 10.1016/j.bbamcr.2012.03.015. Epub 2012 Apr 5. PubMed PMID: 22504301.
3: Phulwani NK, Feinstein DL, Gavrilyuk V, Akar C, Kielian T. 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. J Neurochem. 2006 Dec;99(5):1389-1402. PubMed PMID: 17074064; PubMed Central PMCID: PMC2423669.
4: Drew PD, Storer PD, Xu J, Chavis JA. Hormone regulation of microglial cell activation: relevance to multiple sclerosis. Brain Res Brain Res Rev. 2005 Apr;48(2):322-7. Epub 2005 Jan 19. Review. PubMed PMID: 15850670; PubMed Central PMCID: PMC2819756.
5: Kielian T, McMahon M, Bearden ED, Baldwin AC, Drew PD, Esen N. S. aureus-dependent microglial activation is selectively attenuated by the cyclopentenone prostaglandin 15-deoxy-Delta12,14- prostaglandin J2 (15d-PGJ2). J Neurochem. 2004 Sep;90(5):1163-72. PubMed PMID: 15312171; PubMed Central PMCID: PMC2366814.
6: Hashimoto T, Ohata H, Momose K. Itch-scratch responses induced by lysophosphatidic acid in mice. Pharmacology. 2004 Sep;72(1):51-6. PubMed PMID: 15292655.
7: Garg TK, Chang JY. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21;3:5. PubMed PMID: 12659653; PubMed Central PMCID: PMC153521.
8: Lai JM, Wu S, Huang DY, Chang ZF. Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells. Mol Cell Biol. 2002 Nov;22(21):7581-92. PubMed PMID: 12370305; PubMed Central PMCID: PMC135659.
9: Holmström C, James S, Egan S, Kjelleberg S. Inhibition of common fouling organisms by marine bacterial isolates ith special reference to the role of pigmented bacteria. Biofouling. 1996;10(1-3):251-9. doi: 10.1080/08927019609386284. PubMed PMID: 22115116.
10: Sallee FR, Sethuraman G, Rock CM. Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder. Acta Psychiatr Scand. 1994 Jul;90(1):4-9. PubMed PMID: 7976448.

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