ROCK2-IN-2

• CAT Number: I019953
• CAS Number: 1995065-79-6
• Molecular Formula: C₁₈H₁₂N₆OS
• Molecular Weight: 360.39
• Purity: ≥95%
• IUPAC Name: N-(1H-indazol-5-yl)-5-[3-(1,3-oxazol-2-yl)phenyl]-1,3,4-thiadiazol-2-amine
• InChI: InChI=1S/C18H12N6OS/c1-2-11(16-19-6-7-25-16)8-12(3-1)17-23-24-18(26-17)21-14-4-5-15-13(9-14)10-20-22-15/h1-10H,(H,20,22)(H,21,24)
• InChIKey: WFSHRQCWPPIEIB-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)C2=NN=C(S2)NC3=CC4=C(C=C3)NN=C4)C5=NC=CO5

ROCK2-IN-2（Cat No.:I019953）is a selective inhibitor of Rho-associated protein kinase 2 (ROCK2), an enzyme involved in various cellular processes, including contraction, motility, and proliferation. By inhibiting ROCK2, this compound modulates signaling pathways associated with smooth muscle contraction and cell migration, making it of interest in cardiovascular and cancer research. ROCK2-IN-2 has shown potential in preclinical studies for its ability to reduce tumor growth and metastasis, particularly in aggressive cancers. Additionally, it may have therapeutic applications in treating vascular disorders and other conditions characterized by abnormal cell behavior.

Reference

[1]. Aicher, Thomas Daniel, et al. INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE. US20180093978A1.